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[38] Strikingly, the first patient was described to have many of the classic complications of the disease, including arthritis related to abnormal bone mechanics, cranial nerve palsies associated with an enlarging skull, and malignant transformation of a tumor of the radius which ultimately proved fatal. Paget's post-mortem autopsy evaluation showed ”bones of the vault of this skull were in every part increased to about four times the normal thickness,” and microscopic evaluation showed evidence of both bone erosion and abnormal remodeling. Although he incorrectly attributed the findings to a process of chronic inflammation, having ruled out tumor and hypertrophy as alternative etiologies, these prescient observations of a mixed destructive/regenerative process correspond to the modern understanding of the disease. Society and culture Edit. External links Edit. The body is supposed to break down old bone and replenish it over time. Paget's disease of bone accelerates that process which includes the regrowth of new bone. The resulting accelerated bone growth leads to abnormal growth, including deformities and bones that are prone to fractures. Paget's disease can often go completely without symptoms and inadvertently might be detected only through an X-ray or a surgery performed for a different reason. However, there are patients who have complaints from Paget's disease. These include: Medical experts don't really know how Paget's disease is acquired or what causes it to develop. Scientists suggest that the causes are a combination of both genetic and environmental factors, with some theories reporting a possible association with exposure to a virus. The prevalence of Paget's disease of bone has been decreasing in recent years. Some scientists have associated this with the development of vaccines for certain types of viruses, including measles.
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