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This intense cellular activity produces a chaotic picture of trabecular bone (”mosaic” pattern), rather than the normal linear lamellar pattern. The resorbed bone is replaced and the marrow spaces are filled by an excess of fibrous connective tissue with a marked increase in blood vessels, causing the bone to become hypervascular. The bone hypercellularity may then diminish, leaving a dense ”pagetic bone,” also known as burned-out Paget's disease. A later phase of the disease is characterized by the replacement of normal bone marrow with highly vascular fibrous tissue. [24] Diagnosis Edit. The first clinical manifestation of Paget's disease is usually an elevated alkaline phosphatase in the blood. [6] Paget's disease may be diagnosed using one or more of the following tests: Differential diagnosis Edit. Although initially diagnosed by a primary care physician, endocrinologists (internal medicine physicians who specialize in hormonal and metabolic disorders), rheumatologists (internal medicine physicians who specialize in joint and muscle disorders), orthopedic surgeons, neurosurgeons, neurologists, oral and maxillofacial surgeons, and otolaryngologists are generally knowledgeable about treating Paget's disease and may be called upon to evaluate specialized symptoms. It can sometimes be difficult to predict whether a person with Paget's disease, who otherwise has no signs or symptoms of the disorder, will develop symptoms or complications (such as a bone fracture) in the future. [ citation needed ] The goal of treatment is to relieve bone pain and prevent the progression of the disease. Esportes da sorte 1.Sofascore also provides the best way to follow the live score of this game with various sports features. Therefore, you can: More details : Bristol rovers vs rochdale.
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