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Also, females with severe form may die undiagnosed in a neonatal adrenal crisis more often than males [15]. Pubertal status. Psychiatric disorders have so far not been reported in studies with exclusively 3βHSD2D recruited [119]. In studies of CAH psychiatric diseases have only occasionally been investigated and these have shown an increased rate [103, 120, 121], especially of depression [122], alcohol misuse [120, 121], and suicidality [103, 120]. Inhaltsverzeichnis. All classes of steroid hormones are synthesized from the common precursor cholesterol. The synthesis of sex steroid hormones is carried out under the catalysis of a series of enzymes, and the genes encoding these enzymes include hsd3b1 , hsd11b2 , hsd17b1 , hsd17b3 , and hsd20b2 of the beta-hydroxysteroid dehydrogenases (β-HSDs) superfamily, and cyp11a1 , cyp11b , cyp17a1 , cyp19a1a , and cyp21a1 of the cytochrome P450 (cP450) superfamily (Tokarz et al., 2015). Hsd3b1 is responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors in order to form Δ4-3-ketosteroid (Nakamoto et al., 2012). In da club tradução.
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