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The use of IHC to assess the ER and PR status of breast cancers in formalin-fixed, paraffin-embedded (FFPE) tissue sections of cancer samples is now a routine part of pathology practice worldwide and is recommended to be performed in all primary invasive breast carcinomas and on recurrent or metastatic tumors. The hormone receptor status of a breast cancer helps the doctor to decide whether the patient should be offered hormonal therapy or other treatments. Confira abaixo casa de aposta do ronaldinho a notícia sobre as Loterias na Íntegra. If the breast cancer cells have hormone receptors, then these medications could help to slow or even stop their growth. Patients with ER-positive cancers are highly receptive to endocrine therapy and have a higher chance of survival [1]. If the cancer is hormone-receptor-negative (no hormone receptors are present), then hormonal therapy is unlikely to work. In this case, other kinds of treatment should be sought. Figure 1 shows the block diagram of our proposed system. In our previous work, indicated by blue boxes and arrows, we have reported our initial work on cell detection [2], positively and negatively stained (PN) cell classification [3] and weakly, moderately, or strongly stained (WMS) cell classification [4] on their own. In this work, we integrated the three stages into a single system, experimented with each stage with the same set of images, and evaluated their performances objectively and transitively in order to observe the overall performance of the integrated system. Positively and negatively stained cells are quite distinguishable based on their color properties, i.e., negative cells are stained with a blue/purple hue, while positive cells are stained with a brown hue.
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