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Subsequently, ACTH drives the accumulation of β-hydroxy-Δ5-steroids pregnenolone, 17-hydroxypregnenolone, and DHEA, and their sulfates [25]. These precursor steroids cannot compensate for the cortisol and aldosterone deficiencies resulting in electrolyte disturbances and SW in most patients [12]. In the peripheral tissues, the intact isoenzyme HSD3B1 enzyme converts circulating DHEA to testosterone [16]. The human type I isoenzyme 3βHSD is the isoenzyme, encoded by HSD3B1 gene and is expressed in peripheral tissue including skin, mammary glands, and placenta [9, 11, 14]. It has 372 amino acids and shares more than 90% homology with the type II isoenzyme [27, 28]. The human type I isoenzyme 3βHSD catalyzes transformation of DHEA into sex steroids including testosterone and estradiol [9]. The phenotype of 3βHSD2D varies according to the genetic defect from severe SW form in neonates to mild menstrual disorders in older females [13, 15, 20]. In normal 46,XY fetuses, androgens are required for penile development including the urethra and fusion of the labial-scrotal folds that normally takes place before 12 weeks of gestation [29]. Pokerth ios.
Grund dafür ist, dass Sie in der Lage sein müssen, diese Spielzüge sowohl mit guten wie mit schlechten Händen zumachen. Das nennt man dann „Balancing der Range“. Wenn Sie 3-Bets nur callen und dann den Flop als Bluff checkraisen, sind Sie leicht auszuspielen.
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