Beta-Hydroxysteroid Dehydrogenase Genes in Orange-Spotted Grouper ( Epinephelus coioides ): Genome-Wide Identification and Expression Analysis During Sex Reversal. Introduction. All classes of steroid hormones are synthesized from the common precursor cholesterol. The synthesis of sex steroid hormones is carried out under the catalysis of a series of enzymes, and the genes encoding these enzymes include hsd3b1 , hsd11b2 , hsd17b1 , hsd17b3 , and hsd20b2 of the beta-hydroxysteroid dehydrogenases (β-HSDs) superfamily, and cyp11a1 , cyp11b , cyp17a1 , cyp19a1a , and cyp21a1 of the cytochrome P450 (cP450) superfamily (Tokarz et al., 2015). Hsd3b1 is responsible for the oxidation and isomerization of Δ5-3β-hydroxysteroid precursors in order to form Δ4-3-ketosteroid (Nakamoto et al., 2012). Hsd11b2 catalyzes the conversion of cortisol to cortisone (Fuller et al., 2012), and also plays a crucial role in the conversion of 11β-OH-androstenedione to 11-ketotestosterone (11-KT) (Tokarz et al., 2015), which affects the production of the most important androgen in teleost fish. Conditional Bet – winorama casino a multi bet on irrelevant outcomes.
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