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A two-state biophysical and molecular model has been proposed to account for the pH and REDOX sensitivity of this and other GPCRs. [16] Function Edit. The function facilitates the fight-or-flight response. Activation of the β 2 adrenoreceptor with long-acting agents such as oral clenbuterol and intravenously-infused albuterol results in skeletomuscular hypertrophy and anabolism. [26] [27] The comprehensive anabolic, lipolytic, and ergogenic effects of long-acting β 2 agonists such as clenbuterol render them frequent targets as performance-enhancing drugs in athletes. [28] Consequently, such agents are monitored for and generally banned by WADA (World Anti-Doping Agency) with limited permissible usage under therapeutic exemptions; clenbuterol and other β 2 adrenergic agents remain banned not as a beta-agonist, but rather an anabolic agent. These effects are largely attractive within agricultural contexts insofar that β 2 adrenergic agents have seen notable extra-label usage in food-producing animals and livestock. While many countries including the United States have prohibited extra-label usage in food-producing livestock, the practice is still observed in many countries. [29] [30] Heart muscle contraction Increase cardiac output (minor degree compared to β 1 ). Increases heart rate[20] in sinoatrial node (SA node) (chronotropic effect). Increases atrialcardiac muscle contractility. (inotropic effect). Increases contractility and automaticity[20] of ventricular cardiac muscle.
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